In this Position Piece, I critically reflect upon some epistemological and political issues of interventions and intervention-oriented research in post-trafficking mental health care. I discuss three loci of friction within the framework of a critical global mental health approach to trafficking aftercare: ethnography, biomedical studies, and post-trafficking care. I address these loci through three case studies: two drawn from my own ethnographic fieldwork and one from a recent systematic review of biomedical studies on post-trafficking mental health. My discussion focuses on the limits of such activities when conducted as isolated interventions and highlights the need for radical interdisciplinary and participatory approaches.