As an emerging subfield of medical anthropology with roots in histories and geographies of colonial and international health, critical global health studies reflects both changing modes of health practice and the centering of critique as a core anthropological endeavor. This special section seeks to analyze and reflect on the meanings, valences, affects, and entailments of anthropological critique, taking the rise of global health and flourishing of global health ethnography as key sites of investigation. Each of the contributing pieces is oriented around a global health object or technology.